Does lithium prevent relapse following successful electroconvulsive therapy for major depression? A systematic review and meta‐analysis

  title={Does lithium prevent relapse following successful electroconvulsive therapy for major depression? A systematic review and meta‐analysis},
  author={Simon Lambrichts and Johan Detraux and Kristof Vansteelandt and Axel Nordenskj{\"o}ld and Jasmien Obbels and Didier Schrijvers and Pascal Sienaert},
  journal={Acta Psychiatrica Scandinavica},
The risk of relapse following successful antidepressant treatment, including electroconvulsive therapy (ECT), is substantial. Lithium has been suggested to effectively prevent relapse, yet data remain limited and inconclusive. We performed a systematic review and meta‐analysis to examine the efficacy of continuation treatment with lithium in preventing relapse following a successful acute course of ECT in patients with major depression, in comparison to continuation treatment without lithium… 

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Relapse Prevention

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There is strong evidence that lithium can help prevent relapses in the first 6 months after index ECT, however, there are several unanswered questions about its use post-ECT, including optimal target blood level, duration of use, and concomitant antidepressant choice.

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