Does iron chelation therapy improve survival in regularly transfused lower risk MDS patients? A multicenter study by the GFM (Groupe Francophone des Myélodysplasies).

Abstract

BACKGROUND Iron chelation therapy (CT) improves survival in thalassemia major but its beneficial effects on survival in MDS patients remain uncertain. METHODS We analyzed, by multivariate analysis, survival and causes of deaths in 97 low or intermediate 1 IPSS patients regularly transfused as outpatients, chelated or not, who were included during a month period and followed for 2.5 years. RESULTS 44 (45%) of patients were not chelated and 53 (55%) received CT, mainly with deferoxamine, for at least 6 months (median duration of chelation 36 months, range 6-131+). During the follow-up period, 66 of the 97 patients died, including 51% and 73% of chelated and non-chelated patients, respectively. Median overall survival was 53 months and 124 months in non-chelated and in chelated patients (p<0.0003). Causes of death did not significantly differ between the two groups (p=0.51). In multivariate Cox analysis, adequate chelation was the strongest independent factor associated with better OS. CONCLUSION Iron chelation therapy appears to improve survival in heavily transfused lower risk MDS, but prospective randomized studies are required to confirm our findings, and to determine more precisely the mechanisms of this potential survival benefit.

DOI: 10.1016/j.leukres.2009.12.004
050020102011201220132014201520162017
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@article{Rose2010DoesIC, title={Does iron chelation therapy improve survival in regularly transfused lower risk MDS patients? A multicenter study by the GFM (Groupe Francophone des My{\'e}lodysplasies).}, author={Christian Rose and Sabine Br{\'e}chignac and Dominique Vassilief and Laurent Benjamin Pascal and Aspasia Stamatoullas and Agn{\`e}s Guerci and Dalila Larbaa and F. Dreyfus and Odile Beyne-Rauzy and Marie Pierre Chaury and Lydie Roy and St{\'e}phane Ch{\`e}ze and Pierre Morel and Pierre Fenaux}, journal={Leukemia research}, year={2010}, volume={34 7}, pages={864-70} }