Does intravenous saline infusion compromise the stability of [123I] meta-iodobenzylguanidine?

Abstract

To avoid adverse effects during the administration of [(123)I] meta-iodobenzylguanidine (MIBG), infusion of the drug that has been previously diluted is proposed. Stability of [(123)I] MIBG in sodium chloride solutions is studied, looking for incompatibilities in the formulation. Stability was tested on the basis of the percentage of free [(123)I] iodide on solid-phase extraction. No increase in percentages of free [(123)I] iodide was found in diluted and undiluted samples over time (P>0.05). Intravenous saline infusion of [(123)I] MIBG could be a useful tool for controlling the administration rate, minimizing the side effects and lowering the exposure of the staff to ionizing radiation.

DOI: 10.1097/MNM.0000000000000103

Cite this paper

@article{Martnez2014DoesIS, title={Does intravenous saline infusion compromise the stability of [123I] meta-iodobenzylguanidine?}, author={Teresa Mart{\'i}nez and Tom{\'a}s Chivato and Marta Rold{\'a}n and Elena Mi{\~n}ana}, journal={Nuclear medicine communications}, year={2014}, volume={35 6}, pages={683-5} }