Does intravenous administration of GABA(A) receptor antagonists induce both descending antinociception and touch-evoked allodynia?

@article{Koyama1998DoesIA,
  title={Does intravenous administration of GABA(A) receptor antagonists induce both descending antinociception and touch-evoked allodynia?},
  author={Natsu Koyama and Fumihiko Hanai and Toshikatsu Yokota},
  journal={Pain},
  year={1998},
  volume={76 3},
  pages={
          327-36
        }
}
Effects of intravenous administration of picrotoxin (PTX), a GABA(A) receptor antagonist, upon activities of wide dynamic range (WDR) neurons in the lumbar spinal cord were studied in urethane-chloralose anesthetized cats. Intravenous PTX augmented tactile evoked responses of WDR neurons, but reduced nociceptive responses dose-dependently. Spinal transection reversed the suppression of nociceptive responses. In the spinal cat, intravenous PTX enhanced the tactile evoked response. Intravenous… CONTINUE READING

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