Does interleukin-17 play the villain in nonalcoholic steatohepatitis?

@article{Kisseleva2014DoesIP,
  title={Does interleukin-17 play the villain in nonalcoholic steatohepatitis?},
  author={Tatiana Kisseleva},
  journal={Hepatology},
  year={2014},
  volume={59 5},
  pages={
          1671-2
        }
}
I nterleukin (IL)-17 (IL-17A) is a member of the Th17 family of cytokines comprised of IL-17A, IL-17F, IL-17B, IL-17C, and IL-17E. IL-17 signaling plays a critical role in mediating autoimmunity, such as the autoimmune inflammatory diseases psoriasis and rheumatoid arthritis that respond to anti-IL-17 biological therapies. More recently, IL-17 has been implicated in liver, lung, and skin fibrosis, and in tumorigenesis. Mainly produced by CD4 Th17 cells, IL-17 mediates its biological function by… CONTINUE READING

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