Does interference between replication and transcription contribute to genomic instability in cancer cells?

@article{Tuduri2010DoesIB,
  title={Does interference between replication and transcription contribute to genomic instability in cancer cells?},
  author={Sandie Tuduri and Laure Crabbe and H{\'e}l{\`e}ne Tourri{\`e}re and Arnaud Coquelle and Philippe Pasero},
  journal={Cell cycle},
  year={2010},
  volume={9 10},
  pages={1886-92}
}
We have recently reported that topoisomerase 1 (Top1) cooperates with ASF/SF2, a splicing factor of the SR family, to prevent unscheduled replication fork arrest and genomic instability in human cells. Our results suggest that Top1 execute this function by suppressing the formation of DNA-RNA hybrids during transcription, these so-called R-loops interfering with the progression of replication forks. Using ChIP-chip, we have shown that γ-H2AX, a marker of DNA damage, accumulates at gene-rich… CONTINUE READING

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