Does insulin dysfunction play a role in Alzheimer's disease?

  title={Does insulin dysfunction play a role in Alzheimer's disease?},
  author={Laura Elisa Gasparini and William Joseph Netzer and Paul Greengard and Huaxi Xu},
  journal={Trends in pharmacological sciences},
  volume={23 6},
Age-related changes in hormone levels are determinants of a variety of human diseases. Insulin is known to affect numerous brain functions including cognition and memory, and several clinical studies have established links between Alzheimer's disease (AD), insulin resistance and diabetes mellitus. These are reinforced by biological studies that reveal the effects of insulin on the molecular and cellular mechanisms that underlie the pathology of AD. For example, insulin regulates phosphorylation… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Topics from this paper.
104 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 104 extracted citations

Similar Papers

Loading similar papers…