Does hypoxia play a role in infantile hemangioma?

@article{Jong2016DoesHP,
  title={Does hypoxia play a role in infantile hemangioma?},
  author={Sophie de Jong and Tinte Itinteang and Aaron H. J. Withers and Paul Frank Davis and Swee T Tan},
  journal={Archives of Dermatological Research},
  year={2016},
  volume={308},
  pages={219-227}
}
Infantile hemangioma (IH), the most common tumor of infancy, is characterized by rapid growth during infancy, followed by spontaneous involution over 5–10 years. Certain clinical observations have led to the suggestion that IH is triggered and maintained by hypoxia. We review the literature on the possible role of hypoxia in the etiology of IH, in particular, (1) the role of hypoxia inducible factor-1α (HIF-1α) and its downstream targets including GLUT-1 and VEGF; (2) the pathophysiological… CONTINUE READING
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