Does growth hormone releasing factor desensitize the somatotroph? Interpretation of responses of growth hormone during and after 10-hour infusion of GRF 1-29 amide in man.

@article{Davis1986DoesGH,
  title={Does growth hormone releasing factor desensitize the somatotroph? Interpretation of responses of growth hormone during and after 10-hour infusion of GRF 1-29 amide in man.},
  author={Joseph R. Davis and Michael C. Sheppard and R A Shakespear and Seamus S. Lynch and Richard N. Clayton},
  journal={Clinical endocrinology},
  year={1986},
  volume={24 2},
  pages={135-40}
}
It is unclear whether growth hormone releasing factor (GRF) administration in vivo may desensitize the somatotroph. To investigate this possibility we have examined the effects of 10-h infusion of the equipotent 1-29 amide analogue of hpGRF on serum GH levels and on the subsequent GH response to a bolus dose of GRF (1-29). Four normal adult males received… CONTINUE READING