Does glutamine contribute to immunosuppression after major burns?

  title={Does glutamine contribute to immunosuppression after major burns?},
  author={M. Parry-Billings and Jacqueline Evans and Phillip C Calder and Eric A. Newsholme},
  volume={336 8714},
The effects of glutamine concentration on the rates of lymphocyte proliferation after mitogenic stimulation and of phagocytosis by macrophages were investigated in vitro. A decrease in the glutamine concentration in culture medium from 0.6 to 0.05 mmol/l greatly decreased the rate of proliferation of human lymphocytes and of phagocytosis by mouse macrophages. In patients with major burn injury plasma glutamine concentration was 58% lower than that in normal controls and it remained low for at… CONTINUE READING

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