Does genetic variation in the Delta6-desaturase promoter modify the association between alpha-linolenic acid and the prevalence of metabolic syndrome?

@article{Truong2009DoesGV,
  title={Does genetic variation in the Delta6-desaturase promoter modify the association between alpha-linolenic acid and the prevalence of metabolic syndrome?},
  author={Hong Truong and Julia R Dibello and Edward A Ruiz-Narv{\'a}ez and Peter Kraft and Hannia Campos and Ana Baylin},
  journal={The American journal of clinical nutrition},
  year={2009},
  volume={89 3},
  pages={920-5}
}
BACKGROUND Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with protection against components of the metabolic syndrome, but the role of alpha-linolenic acid (ALA), the metabolic precursor of EPA and DHA, has not been studied. The Delta(6)-desaturase enzyme converts ALA into EPA and DHA, and genetic variation in the Delta(6)-desaturase gene (FADS2) may affect this conversion. OBJECTIVES We hypothesize that high ALA is associated with a lower prevalence of the… CONTINUE READING

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