Does gene expression analysis inform us in rheumatoid arthritis?

@article{Hupl2009DoesGE,
  title={Does gene expression analysis inform us in rheumatoid arthritis?},
  author={Thomas H{\"a}upl and Bruno Stuhlm{\"u}ller and Andreas Gr{\"u}tzkau and Andreas Radbruch and Gerd R{\"u}diger Burmester},
  journal={Annals of the Rheumatic Diseases},
  year={2009},
  volume={69},
  pages={i37 - i42}
}
Transcription profiling has become a standard technology in research. It is mainly applied in the search for biomarkers to improve diagnostic and prognostic classification, to quantify disease activity and to predict or indicate response to therapy. This review will focus on rheumatoid arthritis and discuss considerations for sample selection, prerequisites for functional interpretation of data and the current status of information deduced in the field of biomarkers for the various clinical… 

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References

SHOWING 1-10 OF 81 REFERENCES

Molecular discrimination of responders and nonresponders to anti-TNFalpha therapy in rheumatoid arthritis by etanercept

Early downregulation of expression levels secondary to TNFα neutralization was associated with good clinical responses, and underline that early gene expression profiling is instrumental in identifying candidate biomarkers to predict therapeutic outcomes of anti-TNFα treatment regimes.

Gene profiling in white blood cells predicts infliximab responsiveness in rheumatoid arthritis

As indicators of responsiveness to a tumour necrosis factor (TNF)α blocking agent (infliximab) are lacking in rheumatoid arthritis, we have used gene profiling in peripheral blood mononuclear cells

Rheumatoid arthritis is a heterogeneous disease: evidence for differences in the activation of the STAT-1 pathway between rheumatoid tissues.

Differences in the gene expression profiles provide a unique perspective for distinguishing different pathogenetic RA subsets based on molecular criteria, and reflect important aspects of molecular variation that are relevant for understanding the biologic dysregulation underlying these subsets of RA.

Effect of infliximab on mRNA expression profiles in synovial tissue of rheumatoid arthritis patients

We examined the gene expression profiles in arthroscopic biopsies retrieved from 10 rheumatoid arthritis patients before and after anti-TNF treatment with infliximab to investigate whether such

A genome-scale assessment of peripheral blood B-cell molecular homeostasis in patients with rheumatoid arthritis.

Parts of the multifaceted role B-cells play in RA pathogenesis are outlined in which immune dysregulation in RA modulates B-cell biology and thereby contributes to the induction and perpetuation of a pathogenic humoral immune response.

Gene Expression Profiling of Rheumatoid Arthritis Synovial Cells Treated with Antirheumatic Drugs

The authors aimed to elucidate the molecular effects of typical antirheumatic drugs on the expression profile of RA-related genes expressed in activated synovial fibroblasts to give the first insight into the mechanisms of action of common antir heumatic drugs used for the treatment of arthritides.

The genetics of rheumatoid arthritis: influences on susceptibility, severity, and treatment response.

There has been an explosion of knowledge of genetic variations among different populations and the influence of genetics on complex diseases such as rheumatoid arthritis, and pharmacogenetic markers may prove to be clinically useful.

Responsiveness to anti-tumour necrosis factor α therapy is related to pre-treatment tissue inflammation levels in rheumatoid arthritis patients

It is indicated that patients with a high level of tissue inflammation are more likely to benefit from anti-TNFα treatment, compared to those who did not show clinical improvement.

Rheumatoid arthritis subtypes identified by genomic profiling of peripheral blood cells: assignment of a type I interferon signature in a subpopulation of patients

The IFN type I signature defines a subgroup of patients with RA, with a distinct biomolecular phenotype, characterised by increased activity of the innate defence system, coagulation and complement cascades, and fatty acid metabolism.

Interaction between rheumatoid arthritis and pregnancy: correlation of molecular data with clinical disease activity measures.

Comparative analysis of PBMC expression profiles from RA patients during and after pregnancy with RADAI and CRP revealed a correlation of these disease activity parameters predominantly with monocyte transcripts, suggesting that molecular activation of T lymphocytes may remain clinically unrecognized postpartum.
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