Does farm fungicide use induce azole resistance in Aspergillus fumigatus?

  title={Does farm fungicide use induce azole resistance in Aspergillus fumigatus?},
  author={Rui Kano and Erina Kohata and Akira Tateishi and Somay Yamagata Murayama and Dai Hirose and Yasuko Shibata and Yasuhiro Kosuge and Hiroaki Inoue and Hiroshi Kamata and Atsuhiko Hasegawa},
  journal={Medical mycology},
  volume={53 2},
Azole resistance of Aspergillus fumigatus isolates has been reported worldwide and it would appear to be mainly due to a point mutation in the 14α-sterol demethylase (CYP51A) gene, which is the target enzyme for azoles. The mutation has been confirmed in isolates from patients who received long-term itraconazole (ITZ) therapy and from agricultural fields where high levels of azole fungicides were employed. However, the relationship between farm environments and azole-resistant A. fumigatus has… CONTINUE READING
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