Does expression of the retrogene UTP14c in the ovary pre-dispose women to ovarian cancer?

  title={Does expression of the retrogene UTP14c in the ovary pre-dispose women to ovarian cancer?},
  author={J. Rohozinski and C. Edwards and M. Anderson},
  journal={Medical hypotheses},
  volume={78 4},
  • J. Rohozinski, C. Edwards, M. Anderson
  • Published 2012
  • Biology, Medicine
  • Medical hypotheses
  • It has been previously shown that the spermatogenesis associated retrogene, UTP14c, is expressed in over 50% of normal human ovaries and 80% of ovarian cancers. UTP14c is located on chromosome 13 as an intronless copy of the X-linked housekeeping gene, UTP14a. Like all spermatogenesis associated retrogenes, UTP14c is expressed in the testis and is essential for sperm production. It has no known role in the female and is not normally expressed in any cells or organs outside of the gonads. By… CONTINUE READING
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