Does ethanol act preferentially via selected brain GABAA receptor subtypes? the current evidence is ambiguous.

@article{Korpi2007DoesEA,
  title={Does ethanol act preferentially via selected brain GABAA receptor subtypes? the current evidence is ambiguous.},
  author={Esa R Korpi and Fabian Debus and A M Lind{\'e}n and C{\'e}cile Mal{\'e}cot and Elli Lepp{\"a} and Olga Vekovischeva and Holger Rabe and Ingo B{\"o}hme and M Isabel Aller and William Wisden and Hartmut L{\"u}ddens},
  journal={Alcohol},
  year={2007},
  volume={41 3},
  pages={163-76}
}
In rodent models, gamma-aminobutyric acid A (GABAA) receptors with the alpha6 and delta subunits, expressed in the cerebellar and cochlear nucleus granule cells, have been linked to ethanol sensitivity and voluntary ethanol drinking. Here, we review the findings. When considering both in vivo contributions and data on cloned receptors, the evidence for direct participation of the alpha6-containing receptors to increased ethanol sensitivity is poor. The alpha6 subunit-knockout mouse lines do not… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 33 extracted citations

Similar Papers

Loading similar papers…