Does estrogen receptor beta play a significant role in human reproduction?

Abstract

Estrogens are essential regulators of fertility and bind to estrogen receptors (ERs) ERalpha and ERbeta. The extent to which signalling through ERbeta modulates human fertility is still unclear. Immunohistochemistry revealed that many cells within male and female reproductive systems synthesize ERbeta. Studies using mice lacking functional ERbeta… (More)

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