Does epithelial sodium channel hyperactivity contribute to cystic fibrosis lung disease?

  title={Does epithelial sodium channel hyperactivity contribute to cystic fibrosis lung disease?},
  author={Carey A Hobbs and Chong Da Tan and Robert Tarran},
  journal={The Journal of physiology},
  volume={591 18},
  Airway epithelia absorb Na+ through the epithelial Na+ channel (ENaC) and secrete Cl- through the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. This balance maintains sufficient airway surface liquid hydration to permit efficient mucus clearance, which is needed to maintain sterility of the lung. Cystic fibrosis (CF) is a common autosomal recessive inherited disease caused by mutations in the CFTR gene that lead to the reduction or elimination of the CFTR protein… CONTINUE READING


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