Does elevated nitric oxide production enhance the release of prostacyclin from shear stressed aortic endothelial cells?

@article{Wang1997DoesEN,
  title={Does elevated nitric oxide production enhance the release of prostacyclin from shear stressed aortic endothelial cells?},
  author={Wenhui Wang and Scott L. Diamond},
  journal={Biochemical and biophysical research communications},
  year={1997},
  volume={233 3},
  pages={748-51}
}
Nitric oxide (NO) enhances prostacyclin (PGI2) production in agonist-stimulated endothelial cells, while peroxynitrite formed from NO and superoxide anion has been shown to activate cyclooxygenase. Using cultured bovine aortic endothelial cells (BAEC) exposed to arterial levels of laminar shear stress of 25 dynes/ cm2, we tested the hypothesis that NO mediated the elevated synthesis of PGI2 by shear stressed endothelium. Shear stress caused a large and rapid burst and sustained release of NO… CONTINUE READING

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