Corpus ID: 3310961

Does daily folic acid supplementation reduce methotrexate efficacy?

  title={Does daily folic acid supplementation reduce methotrexate efficacy?},
  author={A. Cline and J. Jorizzo},
  journal={Dermatology online journal},
  volume={23 11}
  • A. Cline, J. Jorizzo
  • Published 2017
  • Medicine
  • Dermatology online journal
  • Methotrexate is a mainstay treatment for autoimmune and inflammatory conditions in the field of Dermatology. However, in some patients, its use is associated with significant side effects and toxicity. Folate supplementation with either folic acid or folinic acid often mitigates side effects and reduces the incidence of systemic toxicity related to methotrexate. Although the value of methotrexate is clear, debate remains about folate supplementation. There is little agreement about the proper… CONTINUE READING
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