Does cytokine gene polymorphism affect steroid responses in idiopathic nephrotic syndrome?

@article{Tripathi2008DoesCG,
  title={Does cytokine gene polymorphism affect steroid responses in idiopathic nephrotic syndrome?},
  author={Gaurav Tripathi and Tabrez Jafar and K. Mandal and Abbas Ali Mahdi and Shally Awasthi and Raj Kumar Sharma and Alok Kumar and Sanjeev Gulati and Suraksha Agrawal},
  journal={Indian journal of medical sciences},
  year={2008},
  volume={62 10},
  pages={383-91}
}
BACKGROUND Immunological responses may be possibly involved in the pathogenesis of idiopathic nephrotic syndrome (INS). Cytokines act as a potent immunomodulator. Pathogenesis of INS is associated with Th1 and Th2 cytokines imbalance. AIMS, SETTINGS AND DESIGN: We have investigated the association of IL-4, IL-6, and TNF-alpha gene polymorphisms and analyzed the data to evaluate the effect of these polymorphisms on the pathogenesis and clinical course of INS. MATERIALS AND METHODS One hundred… CONTINUE READING