Does combination T4 and T3 therapy make sense?

  title={Does combination T4 and T3 therapy make sense?},
  author={Michael T. McDermott},
  journal={Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists},
  volume={18 5},
OBJECTIVE To evaluate the existing evidence regarding the combined use of levothyroxine and liothyronine to treat hypothyroidism. METHODS Eleven published randomized controlled trials evaluating the efficacy and safety of combined levothyroxine and liothyronine therapy for hypothyroidism were reviewed and summarized. Related basic and clinical research findings were also incorporated for perspective. RESULTS An initial randomized controlled trial reported symptomatic improvement in… CONTINUE READING