• DOI:10.1016/S0140-6736(96)11222-8
Corpus ID: 24643796

Does central obesity reflect “Cushing's disease of the omentum”?

@article{Bujalska1997DoesCO,
  title={Does central obesity reflect “Cushing's disease of the omentum”?},
  author={I. Bujalska and S. Kumar and P. Stewart},
  journal={The Lancet},
  year={1997},
  volume={349},
  pages={1210-1213}
}

• I. Bujalska, S. Kumar, P. Stewart
• Published 1997
• Medicine
• The Lancet

BACKGROUND Central obesity results in a cluster of metabolic abnormalities contributing to premature death. Glucocorticoids regulate adipose-tissue differentiation, function, and distribution, and in excess, cause central obesity. Glucocorticoid hormone action is, in part, controlled by two isoforms of the enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) which interconverts hormonally active cortisol to inactive cortisone. We studied cortisol metabolism within different adipose tissue… Expand

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