Does carbamazepine-induced reduction of plasma haloperidol levels worsen psychotic symptoms?

Abstract

Seven psychotic patients' plasma haloperidol levels, determined with gas-liquid chromatography, fell a mean of 60% when carbamazepine treatment was instituted. Two patients' levels became undetectable, and their symptoms worsened. Haloperidol level monitoring may be required for patients given both haloperidol and carbamazepine.

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@article{Arana1986DoesCR, title={Does carbamazepine-induced reduction of plasma haloperidol levels worsen psychotic symptoms?}, author={George W. Arana and Donald C . Goff and Hylar L Friedman and M L Ornsteen and David J Greenblatt and Belinda Black and Richard I. Shader}, journal={The American journal of psychiatry}, year={1986}, volume={143 5}, pages={650-1} }