Does calorie restriction induce mitochondrial biogenesis? A reevaluation.

  title={Does calorie restriction induce mitochondrial biogenesis? A reevaluation.},
  author={Chad Hancock and D Han and Kazuhiko Higashida and Sang Hyun Kim and John O. Holloszy},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={25 2},
It has been reported that 30% calorie restriction (CR) for 3 mo results in large increases in mitochondrial biogenesis in heart, brain, liver, and adipose tissue, with concomitant increases in respiration and ATP synthesis. We found these results surprising, and performed this study to determine whether 30% CR does induce an increase in mitochondria in heart, brain, liver, adipose tissue, and/or skeletal muscle. To this end, we measured the levels of a range of mitochondrial proteins, and mRNAs… CONTINUE READING
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