Does burn wound excision after thermal injury attenuate subsequent macrophage hyperactivity and immunosuppression?

@article{Schwacha2000DoesBW,
  title={Does burn wound excision after thermal injury attenuate subsequent macrophage hyperactivity and immunosuppression?},
  author={Martin G. Schwacha and Markus Werner Kn{\"o}ferl and Irshad H. Chaudry},
  journal={Shock},
  year={2000},
  volume={14 6},
  pages={623-8}
}
Studies have shown that cell mediated immunity is suppressed markedly following thermal injury. Macrophages and the activation of an inflammatory cascade that includes interleukin (IL)-1, IL-6, tumor necrosis factor-alpha (TNFalpha) and PGE2 have been implicated as causative factors. Burn wound excision and grafting is a common clinical practice that decreases patient morbidity and mortality. It is not known, however, if the salutary effects of this procedure are related to modulation of… CONTINUE READING