Does bacterial density in cystic fibrosis sputum increase prior to pulmonary exacerbation?

@article{Stressmann2011DoesBD,
  title={Does bacterial density in cystic fibrosis sputum increase prior to pulmonary exacerbation?},
  author={Franziska Anne Stressmann and Geraint Berian Rogers and Peter Marsh and Andrew K. Lilley and Thomas W. V. Daniels and Mary P. Carroll and Lucas R. Hoffman and Graeme Jones and Collette E Allen and Nilesh Patel and Benjamin Forbes and Andrew Tuck and Kenneth Deans Bruce},
  journal={Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society},
  year={2011},
  volume={10 5},
  pages={357-65}
}
BACKGROUND Cystic Fibrosis (CF) lung disease is characterised by an inexorable decline in lung function, punctuated by periods of symptomatic worsening known as pulmonary exacerbations (referred to here as CFPE). Despite their clinical significance, the cause of CFPE remains undetermined. It has been suggested that an increase in bacterial density may be a trigger, although this has not been shown empirically. METHODS Here, a previously validated quantitative PCR-based approach was used to… CONTINUE READING