Does avascular necrosis of the jaws in cancer patients only occur following treatment with bisphosphonates?

@article{Lenz2005DoesAN,
  title={Does avascular necrosis of the jaws in cancer patients only occur following treatment with bisphosphonates?},
  author={J O Lenz and Beate Steiner-Krammer and Wolfgang Schmidt and Rainer Fietkau and Philipp Mueller and Karsten Kurt Helmuth Gundlach},
  journal={Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery},
  year={2005},
  volume={33 6},
  pages={395-403}
}
INTRODUCTION In the last decade, bisphosphonates were regularly used to treat osteoporosis and bone pain from diseases such as metastatic breast cancer, multiple myeloma and Paget's disease. Currently, the influence of bisphosphonates in development of avascular osteonecrosis of the jaws has been recognized by various authors. In many cancer patients chemotherapy and medications like steroids have also to be applied. Agreement exists that these drugs can initiate vascular endothelial cell… CONTINUE READING
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