Does antipsychotic withdrawal provoke psychosis? Review of the literature on rapid onset psychosis (supersensitivity psychosis) and withdrawal-related relapse.

@article{Moncrieff2006DoesAW,
  title={Does antipsychotic withdrawal provoke psychosis? Review of the literature on rapid onset psychosis (supersensitivity psychosis) and withdrawal-related relapse.},
  author={Joanna Moncrieff},
  journal={Acta psychiatrica Scandinavica},
  year={2006},
  volume={114 1},
  pages={
          3-13
        }
}
OBJECTIVE To examine the evidence that discontinuation of long-term antipsychotic medication, including clozapine, may provoke a psychotic episode. METHOD Databases were searched and citations scrutinised. RESULTS Evidence for a rapid onset psychosis (supersensitivity psychosis) following clozapine withdrawal was found and weaker evidence that this might occur with some other antipsychotic drugs. Some cases were reported in people without a psychiatric history. It appears that the psychosis… CONTINUE READING

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