Does antipsychotic withdrawal provoke psychosis? Review of the literature on rapid onset psychosis (supersensitivity psychosis) and withdrawal‐related relapse

@article{Moncrieff2006DoesAW,
  title={Does antipsychotic withdrawal provoke psychosis? Review of the literature on rapid onset psychosis (supersensitivity psychosis) and withdrawal‐related relapse},
  author={Joanna Moncrieff},
  journal={Acta Psychiatrica Scandinavica},
  year={2006},
  volume={114}
}
  • J. Moncrieff
  • Published 1 July 2006
  • Psychology, Medicine
  • Acta Psychiatrica Scandinavica
Objective:  To examine the evidence that discontinuation of long‐term antipsychotic medication, including clozapine, may provoke a psychotic episode. 
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185 Citations
Highly Influential Citations
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The aim of the study was to measure the real‐life effect of antipsychotic treatment on remission and recovery rates in already stabilized patients with schizophrenia after 1 year.
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Preliminary data suggest that low doses of atypical antipsychotic medications augmented by psychosocial treatments may delay the onset of psychosis in some individuals.
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Adolescent female with withdrawal psychosis following abrupt termination of ziprasidone
TLDR
The following case report is the first time that this phenomenon has been described in an adolescent patient who has discontinued ziprasidone and reasons for supersensitivity psychosis are explored.
Barriers to stopping neuroleptic (antipsychotic) treatment in people with schizophrenia, psychosis or bipolar disorder
TLDR
There is a good rationale for supporting patients who wish to stop their medication, especially given the patient choice agenda favoured by NICE, and guidelines to summarise evidence on ways to reduce medication would be useful.
Clozapine discontinuation withdrawal symptoms in schizophrenia
TLDR
The evidence for the existence of clozapine-induced withdrawal symptoms is reviewed, and in particular focus on withdrawal-associated psychosis, cholinergic rebound, catatonia and serotonergic discontinuation symptoms.
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References

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Psychosis after neuroleptic withdrawal in a manic-depressive patient.
TLDR
A case of neuroleptic-induced supersensitivity psychosis in a manic-depressive patient is presented and the clinical differentiation of such a withdrawal psychosis from schizophrenic decompensation is discussed.
Psychosis after neuroleptic withdrawal in a manic-depressive patient.
The authors present a case of neuroleptic-induced supersensitivity psychosis in a manic-depressive patient. They discuss the clinical differentiation of such a withdrawal psychosis from schizophrenic…
Supersensitivity psychosis in schizophrenic patients after sudden clozapine withdrawal
In two patients with chronic schizophrenia, who were on clozapine medication for more than 6 months, a sudden withdrawal of the drug resulted in a very pronounced deterioration of the psychosis…
Rebound psychosis: Effect of discontinuation of antipsychotics in Parkinson's disease
To determine whether psychiatrically stable patients with a history of drug‐induced psychosis could be successfully weaned off their antipsychotic drug, we offered consecutive Parkinson disease (PD)…
The consequences of suddenly stopping psychotropic medication in bipolar disorder
TLDR
This review explores current understanding of the effects of psychotropic discontinuation in bipolar disorder with a focus on the discontinuation effects of lithium.
Neuroleptic‐induced supersensitivity psychosis in patients with bipolar affective disorder
TLDR
The authors present 5 cases of supersensitivity psychosis that developed in patients with bipolar affective disorder and the implications for the long‐term course of bipolar Affective disorder are discussed.
Neuroleptic withdrawal in patients meeting criteria for supersensitivity psychosis.
TLDR
The authors' pilot data do not seem to support the existence of supersensitivity psychosis, as the sudden worsening of psychotic symptoms and tardive dyskinesia postulated in the SSP group was not observed on the Brief Psychiatric Rating Scale, the Clinical Global Impressions scale, and the Abbreviated Dyskine Rating Scale.
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TLDR
The case of a 34 year old woman is presented, in whom the return of psychotic symptoms following the discontinuation of neuroleptic medications is attributed to a rebound phenomena as opposed to a relapse of an underlying chronic illness.
Neuroleptic-induced supersensitivity psychosis: retrospective study of schizophrenic inpatients.
TLDR
Using Chouinard's criteria, the authors found 12 probable but no definitive cases of this syndrome while conducting a chart review of 265 hospitalized schizophrenic patients, and six of the 12 patients were subsequently rediagnosed as schizoaffective.
Rebound psychoses following the discontinuation of a high potency neuroleptic.
  • G. J. Kahne
  • Psychology, Medicine
    Canadian journal of psychiatry. Revue canadienne de psychiatrie
  • 1989
TLDR
The case of a 34 year old woman is presented, in whom the return of psychotic symptoms following the discontinuation of neuroleptic medications is attributed to a rebound phenomena as opposed to a relapse of an underlying chronic illness.
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