Does anti-mutated citrullinated vimentin have additional value as a serological marker in the diagnostic and prognostic investigation of patients with rheumatoid arthritis? A systematic review

@article{Luime2010DoesAC,
  title={Does anti-mutated citrullinated vimentin have additional value as a serological marker in the diagnostic and prognostic investigation of patients with rheumatoid arthritis? A systematic review},
  author={Jolanda J Luime and Edgar M. Colin and J. M. W. Hazes and Erik Lubberts},
  journal={Annals of the Rheumatic Diseases},
  year={2010},
  volume={69},
  pages={337 - 344}
}
Objective: To review the diagnostic and prognostic value of anti-mutated citrullinated vimentin (MCV) in rheumatoid arthritis, taking into account the already available serology. Methods: Medline was searched via PubMed (1966 to May 2008) for anti-MCV and related terms, arthritis and arthropathies. Studies with anti-MCV, arthritis/arthropathy, and primary data on diagnosis and/or prognosis were included. Their methodological quality was assessed using the Quality Assessment of Diagnostic… Expand

Paper Mentions

Observational Clinical Trial
The aim of this work is to evaluate the diagnostic value of anti-MCV antibodies in rheamatoid arthritis patients and to correlate its relationtion disease activity and manifestations… Expand
ConditionsAnti-MCV in Rheamatoid Arthritis
InterventionDiagnostic Test
Prediction of radiographic progression in rheumatoid arthritis and the role of antibodies against mutated citrullinated vimentin: results from a 10-year prospective study
TLDR
It is indicated that higher anti-MCV levels add prognostic information compared to their mere presence or absence, and the strength of this prediction was at least as strong as for anti-CCP. Expand
Meta-analysis: compared with anti-CCP and rheumatoid factor, could anti-MCV be the next biomarker in the rheumatoid arthritis classification criteria?
TLDR
Anti-MCV demonstrates comparable diagnostic value to anti-CCP and RF, thus it can be an effective diagnostic marker for RA and may be written into the next authoritative criteria. Expand
Diagnostic value of anti-mutated citrullinated vimentin in comparison to anti-cyclic citrullinated peptide and anti-viral citrullinated peptide 2 antibodies in rheumatoid arthritis: an Italian multicentric study and review of the literature.
TLDR
In this study, a large cohort of RA patients were evaluated and anti-MCV demonstrated lower sensitivity than anti-CCP and VCP2 test, thus not allowing to confirm previously published data. Expand
Anti-Mutated Citrullinated Vimentin (Anti-MCV) Antibodies as a Diagnostic Aid for Rheumatoid Arthritis
TLDR
Anti-MCV is an excellent marker for early diagnosis of RA with high sensitivity and specificity especially when other markers are negative, and collectively give the best result for the diagnosis of rheumatoid disease. Expand
Diagnostic value of antibodies against mutated citrullinated vimentin for rheumatoid arthritis.
TLDR
Anti-MCV could be a better test for diagnosing RA than anti-CCP2, which has a higher sensitivity for RA and a specificity similar to anti- CCP2 resulting in the lowest negative likelihood ratio. Expand
Anti-MCV antibodies predict radiographic progression in Greek patients with very early (<3 months duration) rheumatoid arthritis
TLDR
In patients with very early UA, anti-MCV predict both progression to RA and radiological damage, and therefore, anti -MCV antibody testing may be useful in every day practice. Expand
Antibodies to Mutated citrullinated Vimentin in Rheumatoid Arthritis: Diagnostic Value, Association with Radiological Damage and Axial skeleton Affection
TLDR
Investigation of the diagnostic and prognostic value of anti-mutated citrullinated vimentin (anti-MCV) and its correlation with disease activity, peripheral and axial skeleton affection in rheumatoid arthritis patients found it to be of high sensitivity and specificity. Expand
Predicting factors for disappearance of anti-mutated citrullinated vimentin antibodies in sera of patients with rheumatoid arthritis
TLDR
Different from anti-CCP Ab, anti-MCV Ab in sera from RA patients can disappear in a year; some predicting factors for such negative seroconversion were found, whereas clinical significance of anti- MCV Ab disappearance was undetermined. Expand
Antibodies to Mutated Citrullinated Vimentin in Rheumatoid Arthritis: Diagnostic Value, Association with Radiological Damage and Axial Skeleton Affection
TLDR
Anti-MCV antibodies are promising diagnostic and prognostic marker in RA, with high sensitivity and specificity, and may identify a subset of RA patients with aggressive early erosive disease. Expand
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References

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Antibodies against citrullinated vimentin in rheumatoid arthritis: higher sensitivity and extended prognostic value concerning future radiographic progression as compared with antibodies against cyclic citrullinated peptides.
TLDR
It is shown that when patients with early RA are compared with healthy controls, analysis of anti-MCV yields greater sensitivity and unchanged specificity as compared with analysis ofAnti-CCP also appears to perform better than anti- CCP in identifying poor radiographic prognosis in patients withEarly RA. Expand
Comparison of Anti-mutated Citrullinated Vimentin with Anti-cyclic Citrullinated Peptide and Rheumatoid Factors for the Diagnostic Value of Rheumatoid Arthritis
TLDR
This work investigated a diagnostic value of anti-MCV in comparison with those ofAnti-CCP, and rheumatoid factors (IgM, IgG, and IgA RFs) in RA patients to establish a novel serologic marker for an aid in the diagnosis of RA. Expand
Antibodies to Citrullinated Vimentin are a Specific and Sensitive Marker for the Diagnosis of Rheumatoid Arthritis
TLDR
Assessment of the diagnostic and prognostic utility of a ELISA-based assay with a mutated citrullinated vimentin (MCV) antigen found it to be a specific and sensitive marker for the diagnosis of RA. Expand
Clinical evaluation of anti-mutated citrullinated vimentin by ELISA in rheumatoid arthritis.
TLDR
The performance of the novel anti-MCV ELISA for the diagnosis of RA is similar to that of the anti-CCP2 test, and the combined application of the 2 assays can improve the laboratory diagnostics of RA. Expand
Mutation and citrullination modifies vimentin to a novel autoantigen for rheumatoid arthritis.
TLDR
Antigenic properties of vimentin were determined by mutation and citrullination andAnti-MCV antibodies are a novel diagnostic marker for RA and may allow monitoring and-if confirmed in even larger series of patients-stratification of disease. Expand
Diagnostic value of antibodies against a modified citrullinated vimentin in rheumatoid arthritis
TLDR
The serum ELISA testing for anti-MCV antibodies as well as the anti-CCP-2 assay perform comparably well in the diagnosis of RA, with a reduced specificity in the high-specificity range. Expand
Value of anti-mutated citrullinated vimentin antibodies in diagnosing rheumatoid arthritis
TLDR
Anti-MCV shows comparable sensitivity but lower specificity than that of anti-CCP, and they do not appear to be very useful in the diagnosis of RA. Expand
Antibodies against mutated citrullinated vimentin are a better predictor of disease activity at 24 months in early rheumatoid arthritis than antibodies against cyclic citrullinated peptides.
TLDR
Anti-MCV antibodies are associated with a more severe RA disease, as measured by DAS28, ESR, and swollen joint count over time, compared with anti-CCP2, CCP3, and CCP3.1 antibodies. Expand
Anti-cyclic citrullinated peptide versus anti-Sa antibodies in diagnosis of rheumatoid arthritis in an outpatient clinic for connective tissue disease and spondyloarthritis.
TLDR
The results suggest that presence of anti-Sa antibodies in serum may be useful as a complementary assay when anti-CCP antibodies are negative and RA is suspected. Expand
Antibodies to mutated citrullinated vimentin and disease activity score in early arthritis: a cohort study
TLDR
It is concluded that it is not useful to monitor disease activity with anti-MCV levels, because the correlation between anti- MCV levels and parameters of disease activity was very low. Expand
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