Does androgen insufficiency cause lacrimal gland inflammation and aqueous tear deficiency?

  title={Does androgen insufficiency cause lacrimal gland inflammation and aqueous tear deficiency?},
  author={David A. Sullivan and Kathleen L Krenzer and Benjamin David Sullivan and D B Tolls and I Toda and Mohamad R. Dana},
  journal={Investigative ophthalmology & visual science},
  volume={40 6},
PURPOSE The current investigators have shown that androgen treatment suppresses inflammation and stimulates the function of lacrimal glands in mouse models of Sjögren's syndrome. Recently, others have hypothesized that androgen insufficiency induces an autoimmune process in lacrimal tissue, leading to inflammation, a Sjögren's syndrome-like pathology, and aqueous tear deficiency. The purpose of the present study was to test this hypothesis. METHODS Lacrimal glands were obtained from adult… CONTINUE READING


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