Does alfa lipoic acid prevent liver from methotrexate induced oxidative injury in rats?

@article{akr2015DoesAL,
  title={Does alfa lipoic acid prevent liver from methotrexate induced oxidative injury in rats?},
  author={T. Çakır and A. Başt{\"u}rk and C. Polat and A. Aslaner and H. Durgut and A. {\"O}. Şehirli and M. G{\"u}l and A. V. {\"O}ğ{\"u}nç and Semir G{\"u}l and M. Z. Sabuncuoglu and M. Oruç},
  journal={Acta cirurgica brasileira},
  year={2015},
  volume={30 4},
  pages={
          247-52
        }
}
  • T. Çakır, A. Baştürk, +8 authors M. Oruç
  • Published 2015
  • Medicine
  • Acta cirurgica brasileira
  • PURPOSE To determine the antioxidant and anti-inflammatory effects of alfa lipoic acid (ALA) on the liver injury induced by methotrexate (MTX) in rats. METHODS Thirty two rats were randomly assigned into four equal groups; control, ALA, MTX and MTX with ALA groups. Liver injury was performed with a single dose of MTX (20 mg/kg) to groups 3 and 4. The ALA was administered intraperitonealy for five days in groups 2 and 4. The other rats received saline injection. At the sixth day the rats… CONTINUE READING
    Cytokines in Hepatic Injury
    • 6

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