Does alfa lipoic acid prevent liver from methotrexate induced oxidative injury in rats?

@article{akr2015DoesAL,
  title={Does alfa lipoic acid prevent liver from methotrexate induced oxidative injury in rats?},
  author={Tuğrul Çakır and Ahmet Başt{\"u}rk and Cemal Polat and Arif Aslaner and Himmet Durgut and Ahmet Ozer Sehirli and Mehmet G{\"u}l and Ayliz Velioğlu {\"O}ğ{\"u}nç and Semir G{\"u}l and Mehmet Zafer Sabuncuoğlu and Mehmet Tahir Oruç},
  journal={Acta cirurgica brasileira},
  year={2015},
  volume={30 4},
  pages={
          247-52
        }
}
PURPOSE To determine the antioxidant and anti-inflammatory effects of alfa lipoic acid (ALA) on the liver injury induced by methotrexate (MTX) in rats. METHODS Thirty two rats were randomly assigned into four equal groups; control, ALA, MTX and MTX with ALA groups. Liver injury was performed with a single dose of MTX (20 mg/kg) to groups 3 and 4. The ALA was administered intraperitonealy for five days in groups 2 and 4. The other rats received saline injection. At the sixth day the rats… Expand
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