Does actin bind to the ends of thin filaments in skeletal muscle?

@article{Ishiwata1985DoesAB,
  title={Does actin bind to the ends of thin filaments in skeletal muscle?},
  author={S. Ishiwata and T. Funatsu},
  journal={The Journal of Cell Biology},
  year={1985},
  volume={100},
  pages={282 - 291}
}
  • S. Ishiwata, T. Funatsu
  • Published 1985
  • Medicine, Biology
  • The Journal of Cell Biology
  • We examined whether or not purified actin binds to the ends of thin filaments in rabbit skeletal myofibrils. Phase-contrast, fluorescence, and electron microscopic observations revealed that actin does not bind to the ends of thin filaments of intact myofibrils. However, in I-Z-I brushes prepared by dissolving thick filaments at high ionic strength, marked binding of actin to the free ends, i.e., the pointed ends, of thin filaments was observed when actin was added at an early phase of… CONTINUE READING

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