Does acetaldehyde mediate ethanol action in the central nervous system?

  title={Does acetaldehyde mediate ethanol action in the central nervous system?},
  author={Maria Paola Mascia and Rajani Maiya and Cecilia M Borghese and Ingrid A Lobo and Koji Hara and Tomohiro Yamakura and D H Gong and Michael J. Beckstead},
  journal={Alcoholism, clinical and experimental research},
  volume={25 11},
BACKGROUND Some of the effects of ethanol in the central nervous system are due to changes in function of ligand-gated ion channels. Production of detectable amounts of acetaldehyde, a primary metabolite of ethanol, has been demonstrated in brain homogenates. The aim of this study was to determine whether central actions that are often attributed to ethanol may actually be mediated by acetaldehyde. METHODS The effects of acetaldehyde (1-1000 microM) were tested by two-electrode voltage-clamp… CONTINUE READING
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