Does aberrant activation of the epithelial-mesenchymal trophic unit play a key role in asthma or is it an unimportant sideshow?

@article{Knight2004DoesAA,
  title={Does aberrant activation of the epithelial-mesenchymal trophic unit play a key role in asthma or is it an unimportant sideshow?},
  author={Darryl A Knight and Catherine L Lane and Stephen M Stick},
  journal={Current opinion in pharmacology},
  year={2004},
  volume={4 3},
  pages={251-6}
}
Mechanisms underlying the pathogenesis of asthma remain elusive, although the pathological changes observed in human lungs at autopsy are consistent with those of a well-defined chronic inflammatory process and are related to disease severity. Areas of epithelial metaplasia and damage, and thickening of the sub-epithelial basal lamina, are common findings. Epithelial cell proliferation is accompanied by a concomitant increase in the proliferation of sub-epithelial fibroblasts. Each of these… CONTINUE READING

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