Does a species of Rickettsia play a role in the pathophysiology of Buerger's disease?

  title={Does a species of Rickettsia play a role in the pathophysiology of Buerger's disease?},
  author={Bahare Fazeli and Hassan Ravari and Mahdi Farzadnia},
  pages={334 - 336}
Rickettsia is an intracellular pathogen that attaches to vascular endothelial cell membranes and its genome integrates into the DNA of the host and thereby inhibits apoptosis of the endothelial cells. Rickettsia can infect the body following a flea/louse bite. Rickettsia was suggested as one etiology of Buerger's disease long ago. We report a patient with Buerger's disease for whom a left below-knee amputation was done. Twenty-five biopsies for DNA extraction were obtained from the arteries… 

Figures from this paper

Is Rickettsia the key to solving the puzzle of Buerger’s disease?
In conclusion, the unsolved questions associated with BD might be clarified through studies of the link between BD and Rickettsia, which typically shows a segmental nature and thrombotic events may occur from segmental inflammation.
Detection of Rickettsia Endosymbiont Bemisia Tabaci in the Amputated Limbs of Three Buerger’s Disease Patients
The footprint of Rickettsial infection in tissue specimens obtained from amputees with Buerger's disease was evaluated and it was found that smoking could be the route of pathogen entry into the bloodstreams of the sufferers.
Buerger’s Disease May be a Chronic Rickettsial Infection with Superimposed Thrombosis: Literature Review and Efficacy of Doxycycline in Three Patients
It is hypothesize that BD patients acquired a rickettsial infection far before the onset of BD, and it is postulated that BD is a chronic infection with a member of the family Rickettsiaceae with superimposed thrombosis.
Unexpected inflammation in the sympathetic ganglia in thromboangiitis obliterans: more likely sterile or infectious induced inflammation?
It appears that the inflammation in the SG of TAO patients is more likely a sterile inflammation, and its trigger may be mitochondrial DNA (mtDNA).
Thromboangiitis obliterans episode: autoimmune flare-up or reinfection?
The findings indicate that the trigger of TAO might be Gram-negative bacteria, which can be hidden or immunologically suppressed in the quiescent phase ofTAO, leading to a lower level of TLR4 accompanying the normal level of neopterin.
The Status of Nitric Oxide and its Backup, Heme Oxygenase 1, in Thromboangiitis Obliterans.
Nitric oxide may play a pivotal role in TAO development and its outcome, however, the intact HMOX1 pathway may demonstrate the unique role of NO, which cannot be compensated for by H MOX1 and whose absence may make patients susceptible to developing TAO.


[Buerger's disease: etiologic role of the rickettsiae?].
Specific seroagglutination tests were performed in 70 patients with Buerger's disease to detect possible antibodies to rickettsia, the test being repeated in 8 cases after activation by doxycycline
Rickettsia rickettsii infection protects human microvascular endothelial cells against staurosporine-induced apoptosis by a cIAP(2)-independent mechanism.
Rickettsia rickettsii-induced expression of cIAP2 in host endothelial cells is likely not a major contributor to protection against staurosporine-induced cell death, and the mechanisms underlying the anti-apoptotic effect of infection are explored.
Evaluation of Antibiotic Susceptibilities of Three Rickettsial Species Including Rickettsia felis by a Quantitative PCR DNA Assay
Assessment of the levels of inhibition of Rickettisa felis, R. conorii, and R. typhi in the presence of various antibiotics found them to be susceptible to doxycycline, rifampin, thiamphenicol, and fluoroquinolones, but not to gentamicin, erythromycin, amoxicillin, or trimethoprim-sulfamethoxazole.
Buerger's Disease: Is It a Rickettsiosis?
A serologic study using the direct seroagglutinate method was carried out in 31 patients affected by Buerger's disease, leading to the belief that these pathogenic agents are largely responsible for the development of thromboangiitis obliterans.
Rickettsia rickettsii Infection of Cultured Human Endothelial Cells Induces Heme Oxygenase 1 Expression
The findings indicate that R. rickettsii infection induces HO-1 expression in host endothelial cells and suggest an important role for this enzyme in cellular response to infection, possibly by serving a protective function against oxidative injury.
Adherence of platelets to human endothelial cells infected by Rickettsia rickettsii.
  • D. Silverman
  • Medicine, Biology
    The Journal of infectious diseases
  • 1986
It is suggested that the adherence of platelets to the surface of Rickettsia-infected endothelial cells can contribute to reduction in the number of circulating platelets in blood during human infection.
A century of typhus, lice and Rickettsia.
A review on thromboangiitis obliterans pathophysiology: thrombosis and angiitis, which is to blame?
The cumulative data demonstrate that at the cellular and molecular levels, at least four main components of inflammatory reactions, including endothelial cells, platelets, leukocytes and sensory neurons, might be involved in TAO pathogenesis.
Buerger's Disease: Diagnosis and Management
The condition is no longer a disease of misconceptions; its diagnosis and management should be based on a clear understanding of the pathophysiology, which aids prognosis and the decision to undertake surgical or conservative management.
Rickettsia species (as organisms).
  • H. Winkler
  • Medicine
    Annual review of microbiology
  • 1990