Does a nanomolecule of Carboplatin injected periocularly help in attaining higher intravitreal concentrations?

@article{Shome2009DoesAN,
  title={Does a nanomolecule of Carboplatin injected periocularly help in attaining higher intravitreal concentrations?},
  author={Debraj Shome and Neha Poddar and Vinay Sharma and Uday Sheorey and Girish B. Maru and Arvind D. Ingle and Rajiv Sarin and Shripad Banavali and Rajesh P Dikshit and Vandana Jain and Santosh G. Honavar and Jayesh R. Bellare},
  journal={Investigative ophthalmology \& visual science},
  year={2009},
  volume={50 12},
  pages={
          5896-900
        }
}
PURPOSE To compare intravitreal concentration (VC) of commercially available carboplatin (CAC) and the novel nanomolecule carboplatin (NMC), after periocular injection. METHODS The study was a comparative animal study involving 24 white Sprague-Dawley rats, aged between 6 weeks and 3 months. CAC was bound with a nanoparticulate carrier by co-acervation with a biocompatible and biodegradable protein BSA (bovine serum albumin). The particulate size, binding, and structure of the carrier was… Expand
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