Does a betaretrovirus infection trigger primary biliary cirrhosis?

  title={Does a betaretrovirus infection trigger primary biliary cirrhosis?},
  author={Lizhe Xu and Zhiwei Shen and Linsheng Guo and Brent Fodera and Adrian Keogh and Ruth Elizabeth Joplin and Barbara O'Donnell and James Aitken and William F. Carman and James Neuberger and Andrew O Mason},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={100 14},
Patients with primary biliary cirrhosis develop progressive ductopenia associated with the production of antimitochondrial antibodies that react with a protein aberrantly expressed on biliary epithelial cells and peri-hepatic lymph nodes. Although no specific microbe has been identified, it is thought that an infectious agent triggers this autoimmune liver disease in genetically predisposed individuals. Previous serologic studies have provided evidence to suggest a viral association with… CONTINUE READING
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