Does a Placebo Run-In or a Placebo Treatment Cell Affect the Efficacy of Antidepressant Medications?

@article{Trivedi1994DoesAP,
  title={Does a Placebo Run-In or a Placebo Treatment Cell Affect the Efficacy of Antidepressant Medications?},
  author={Madhukar H. Trivedi and John A. Rush},
  journal={Neuropsychopharmacology},
  year={1994},
  volume={11},
  pages={33-43}
}
During the last decade, there has been an increasing use of a placebo run-in period prior to randomization to active treatments, or placebo in randomized controlled trials aimed at establishing acute phase antidepressant drug efficacy in patients with major depression. This procedure is thought to reduce response rates to placebo treatment after randomization, thereby increasing the drug-placebo difference. Metaanalyses of 101 studies reveal that a placebo run-in does not (1) lower the placebo… CONTINUE READING

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