Does Therapeutic Use of Acetaminophen Cause Acute Liver Failure?

  title={Does Therapeutic Use of Acetaminophen Cause Acute Liver Failure?},
  author={Richard C Dart and Elise J. Bailey},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  • R. Dart, Elise J. Bailey
  • Published 1 September 2007
  • Medicine
  • Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Study Objective. To compare the reported occurrence of liver failure in subjects in prospective trials with that in patients in retrospective reports after repeated use of therapeutic dosages of acetaminophen. 

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Acute liver failure.

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A 59-year-old female patient with arthritis developed liver function abnormalities while taking therapeutic doses of acetaminophen, and has been followed for 2 years since that challenge and remains asymptomatic.

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A 44 year old female, previously on propranolol, phenytoin and phenobarbital, developed hepatotoxicity while on sulindac and acetaminophen containing analgesic and its treatment is suggested.