Does Supplementation with Omega-3 PUFAs Add to the Prevention of Cardiovascular Disease?

  title={Does Supplementation with Omega-3 PUFAs Add to the Prevention of Cardiovascular Disease?},
  author={Evangelos C. Rizos and Moses S. Elisaf},
  journal={Current Cardiology Reports},
  • E. Rizos, M. Elisaf
  • Published 21 April 2017
  • Biology, Medicine
  • Current Cardiology Reports
Purpose of ReviewOmega-3 fatty acids are increasingly used for the protection of cardiovascular disease. The main but not the sole mechanism of action is the reduction of triglyceride levels. In this review, we summarize the effect of omega-3 supplements on all-cause and cardiovascular mortality, myocardial infarction, and stroke from the relevant randomized controlled trials.Recent FindingsTwenty-one randomized controlled trials assessed omega-3 supplementation on mortality and cardiovascular… 
The Effect of Omega-3 Dosage on Cardiovascular Outcomes
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Marine n‐3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer
BACKGROUND Higher intake of marine n‐3 (also called omega‐3) fatty acids has been associated with reduced risks of cardiovascular disease and cancer in several observational studies. Whether
Omega-3 Fatty Acids Improve Size of Lipoproteins and Decrease Electronegative Low-Density Lipoprotein [Ldl(-)] of Brazilian Adults
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Anti-inflammatory and Immunomodulatory Effects of Marine n-3 Polyunsaturated Fatty Acids on Human Health and Diseases
This review will focus on the molecular targets and mechanisms of anti-inflammatory and immunomodulatory effects of n-3 PUFAs on human health and diseases, such as obesity, tumor, diabetes, and autoimmune diseases.
The Supportive Treatment of IgA Nephropathy and Idiopathic Nephrotic Syndrome: How Useful are Omega-3 Polyunsaturated Fatty Acids?
If the beneficial effect of omega-3 PUFAs is predicated on their hypolipidemic action, much higher doses could be used in well-designed randomized-controlled trials (RCTs) to determine if they could produce better renal function outcomes and provide much stronger evidence of their therapeutic benefits in IgAN and INS.


n-3 fatty acids and cardiovascular events after myocardial infarction.
Low-dose supplementation with EPA-DHA or ALA did not significantly reduce the rate of major cardiovascular events among patients who had had a myocardial infarction and who were receiving state-of-the-art antihypertensive, antithrombotic, and lipid-modifying therapy.
ω-3 Fatty acids and lutein + zeaxanthin supplementation for the prevention of cardiovascular disease.
No reduction in the risk of the composite outcomes of CVD mortality and CVD morbidity was observed in the DHA + EPA or lutein + zeaxanthin supplementation groups, and Supplementation with either ω-3 or macular xanthophylls was well tolerated and safe.
Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis.
Overall, omega-3 PUFA supplementation was not associated with a lower risk of all-cause mortality, cardiac death, sudden death, myocardial infarction, or stroke based on relative and absolute measures of association.
A randomized clinical trial on n-3 polyunsaturated fatty acids supplementation and all-cause mortality in elderly men at high cardiovascular risk
  • G. Einvik, Tor Ole Klemsdal, L. Sandvik, E. Hjerkinn
  • Medicine
    European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology
  • 2010
A tendency toward reduction in all-cause mortality in the n-3 PUFA groups reached borderline statistical significance, and the magnitude of risk-reduction suggests that a larger trial should be considered in similar populations.
n-3 fatty acids and cardiovascular outcomes in patients with dysglycemia.
Daily supplementation with 1 g of n-3 fatty acids did not reduce the rate of cardiovascular events in patients at high risk for cardiovascular events.
Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a randomised placebo controlled trial
This study does not support the routine use of dietary supplements containing B vitamins or omega 3 fatty acids for prevention of cardiovascular disease in people with a history of ischaemic heart disease or ischaemia stroke, at least when supplementation is introduced after the acute phase of the initial event.
The effect of dietary omega-3 fatty acids on coronary atherosclerosis. A randomized, double-blind, placebo-controlled trial.
Dietary intake of omega-3 fatty acids modestly mitigates the course of coronary atherosclerosis in humans.
Efficacy of omega-3 fatty acid supplements (eicosapentaenoic acid and docosahexaenoic acid) in the secondary prevention of cardiovascular disease: a meta-analysis of randomized, double-blind, placebo-controlled trials.
The meta-analysis showed insufficient evidence of a secondary preventive effect of omega-3 fatty acid supplements against overall cardiovascular events among patients with a history of cardiovascular disease.
Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease.
Recommendations reflecting the current state of knowledge will be made with regard to both fish consumption and omega-3 fatty acid (plant- and marine-derived) supplementation in the context of recent guidance issued by the US Environmental Protection Agency and the Food and Drug Administration about the presence of environmental contaminants in certain species of fish.