Does Sumoylation Control K2P1/TWIK1 Background K+ Channels?

@article{Feliciangeli2007DoesSC,
  title={Does Sumoylation Control K2P1/TWIK1 Background K+ Channels?},
  author={Sylvain F. Feliciangeli and Sa{\"i}d Bendahhou and Guillaume Sandoz and Pierre Gounon and Markus Reichold and Richard Warth and Michel Lazdunski and Jacques Barhanin and Florian Lesage},
  journal={Cell},
  year={2007},
  volume={130},
  pages={563-569}
}
A novel model for the regulation of cell excitability has recently been proposed. It originates from the observation that the background K(+) channel K2P1 (TWIK1) may be silenced by sumoylation in Xenopus oocytes and that inactivation of the putative sumoylation site (mutation K274E) gives rise to robust current expression in transfected COS-7 cells. Here, we show that only the mutation K274E, and not K274R, is associated with an increase of K2P1 current density, suggesting a charge effect of… CONTINUE READING

Figures and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 40 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 23 REFERENCES

Physiology and pharmacology of two-pore domain potassium channels

D. Kim
  • Curr. Pharm. Des. 11, 2717–2736.
  • 2005
VIEW 1 EXCERPT
HIGHLY INFLUENTIAL

Two-pore-Domain (KCNK) potassium channels: dynamic roles in neuronal function.

  • The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
  • 2003
VIEW 1 EXCERPT
HIGHLY INFLUENTIAL

Properties and modulation of mammalian 2P domain K+ channels

  • Trends in Neurosciences
  • 2001
VIEW 1 EXCERPT
HIGHLY INFLUENTIAL