• Biology, Medicine
• Published in Cell 2007
• DOI:10.1016/j.cell.2007.06.012

Does Sumoylation Control K2P1/TWIK1 Background K+ Channels?

@article{Feliciangeli2007DoesSC,
  title={Does Sumoylation Control K2P1/TWIK1 Background K+ Channels?},
  author={Sylvain F. Feliciangeli and Sa{\"i}d Bendahhou and Guillaume Sandoz and Pierre Gounon and Markus Reichold and Richard Warth and Michel Lazdunski and Jacques Barhanin and Florian Lesage},
  journal={Cell},
  year={2007},
  volume={130},
  pages={563-569}
}

• Sylvain F. Feliciangeli, Saïd Bendahhou, +6 authors Florian Lesage

A novel model for the regulation of cell excitability has recently been proposed. It originates from the observation that the background K(+) channel K2P1 (TWIK1) may be silenced by sumoylation in Xenopus oocytes and that inactivation of the putative sumoylation site (mutation K274E) gives rise to robust current expression in transfected COS-7 cells. Here, we show that only the mutation K274E, and not K274R, is associated with an increase of K2P1 current density, suggesting a charge effect of… CONTINUE READING

View on Elsevier

Open Access

Save to Library

Create Alert

Cite