Does Sleep Flush Wastes From the Brain?

  title={Does Sleep Flush Wastes From the Brain?},
  author={Anthony L. Komaroff},

Glymphatic System Dysfunction: A Novel Mediator of Sleep Disorders and Headaches

This study reviews the current literature on the relationship between the glymphatic system, sleep, and headaches, discusses their roles, and proposes acupuncture as a non-invasive way to focus on the Glymphatic function to improve sleep quality and alleviate headache pain.

The meningeal lymphatic vessels and the glymphatic system: Potential therapeutic targets in neurological disorders

Emerging noninvasive imaging techniques are focused on to evaluate the human glymphatic-mLV system and their potential for preclinical diagnosis and prevention of neurodegenerative diseases.

Clinical Understanding of the Sleep-Immune Connection.

  • J. Bland
  • Psychology, Biology
    Integrative medicine
  • 2022
The clinical approach should be to intervene upstream in the regulation of the fundamental systems that control both sleep and immune function, and not just its effects and symptomatology.

Decreased Gray—White Matter Contrast of [11C]-PiB Uptake in Cognitively Unimpaired Subjects with Severe Obstructive Sleep Apnea

Severe OSA was associated with decreased GM—WM contrast in amyloid tracer uptake, with significant correlation with clinical parameters of smoking and AHI, and the results support and further extend the current understanding of the deleterious effect of severe OSA on proper amyloids clearance.

Review of: "Association of sleep duration in middle and old age with incidence of dementia"

The main finding of this study is that people with a short sleep duration in midlife are at an increased risk of dementia in late life.



Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy.

Ablation of meningeal lymphatic vessels in 5xFAD mice worsened the outcome of mice treated with anti-Aβ passive immunotherapy by exacerbating the deposition of Aβ, microgliosis, neurovascular dysfunction, and behavioural deficits, while therapeutic delivery of vascular endothelial growth factor C improved clearance of A β by monoclonal antibodies.

Glymphatic failure as a final common pathway to dementia

The ties that bind sleep, aging, Glymphatic clearance, and protein aggregation have shed new light on the pathogenesis of a broad range of neurodegenerative diseases, for which glymphatic failure may constitute a therapeutically targetable final common pathway.

Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep

A coherent pattern of oscillating electrophysiological, hemodynamic, and CSF dynamics that appears during non–rapid eye movement sleep is discovered, demonstrating that the sleeping brain exhibits waves of CSF flow on a macroscopic scale, and theseCSF dynamics are interlinked with neural and hemodynamic rhythms.

The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans

It is shown that chronic sleep deprivation strongly increases tau acutely over hours and also drives tau pathology spreading in the brains of mice and humans, suggesting sleep appears to have a direct protective effect on a key protein that drives AD pathology.

β-Amyloid accumulation in the human brain after one night of sleep deprivation

The findings show adverse effects of one-night sleep deprivation on brain ABB and expand on prior findings of higher Aβ accumulation with chronic less sleep.

Sleep Drives Metabolite Clearance from the Adult Brain

It is reported that sleep has a critical function in ensuring metabolic homeostasis and convective fluxes of interstitial fluid increased the rate of β-amyloid clearance during sleep, suggesting the restorative function of sleep may be a consequence of the enhanced removal of potentially neurotoxic waste products that accumulate in the awake central nervous system.

Structural and functional features of central nervous system lymphatics

In searching for T-cell gateways into and out of the meninges, functional lymphatic vessels lining the dural sinuses are discovered, which may call for a reassessment of basic assumptions in neuroimmunology and sheds new light on the aetiology of neuroinflammatory and neurodegenerative diseases associated with immune system dysfunction.

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β

An anatomically distinct clearing system in the brain that serves a lymphatic-like function is described and may have relevance for understanding or treating neurodegenerative diseases that involve the mis-accumulation of soluble proteins, such as amyloid β in Alzheimer's disease.