Does Sequence Conservation Provide Evidence for Biological Function?

@article{Omer2017DoesSC,
  title={Does Sequence Conservation Provide Evidence for Biological Function?},
  author={Seila Omer and Timothy J. Harlow and Johann Peter Gogarten},
  journal={Trends in microbiology},
  year={2017},
  volume={25 1},
  pages={11-18}
}
Finding a signature of purifying selection in a gene is usually interpreted as evidence for the gene providing a function that is targeted by natural selection. This opinion offers a very different hypothesis: purifying selection may be due to removing harmful mutations from the population, that is, the gene and its encoded protein become harmful after a… CONTINUE READING