Does Reconsolidation Occur in Humans?

@article{Schiller2011DoesRO,
  title={Does Reconsolidation Occur in Humans?},
  author={Daniela Schiller and Elizabeth A. Phelps},
  journal={Frontiers in Behavioral Neuroscience},
  year={2011},
  volume={5}
}
  • D. Schiller, E. Phelps
  • Published 24 January 2011
  • Biology, Psychology
  • Frontiers in Behavioral Neuroscience
Evidence for reconsolidation in non-human animals has accumulated rapidly in the last decade, providing compelling` demonstration for this phenomenon across species and memory paradigms. In vast contrast, scant evidence exists for human reconsolidation to date. A major reason for this discrepancy is the invasive nature of current techniques used to investigate reconsolidation, which are difficult to apply in humans. Pharmacological blockade of reconsolidation, for example, has been typically… 

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References

SHOWING 1-10 OF 141 REFERENCES
Preventing the return of fear in humans using reconsolidation update mechanisms
TLDR
The adaptive role of reconsolidation as a window of opportunity to rewrite emotional memories is demonstrated, and a non-invasive technique that can be used safely in humans to prevent the return of fear is suggested.
Characterization of Fear Memory Reconsolidation
TLDR
It is reported that reconsolidation cannot be reduced down to facilitated extinction and application of reminder shock does not result in the reinstatement of the memory, supporting the idea that reactivation of consolidated memories initiates a second time-dependent memory formation process.
Episodic memory reconsolidation: Updating or source confusion?
TLDR
The present study asks whether the reconsolidation effect in human episodic memory can be interpreted as a source discrimination problem; i.e., participants have difficulties remembering which objects were presented during which session, and do not actually incorporate new objects into the reactivated memory.
Dissociating response systems: Erasing fear from memory
Limited efficacy of propranolol on the reconsolidation of fear memories.
TLDR
Systemic administration of propranolol is found to disrupts the reconsolidation of Pavlovian FC and that its injection following a retrieval elicited by cue exposure also interferes with the reconsideration of contextual FC.
Human reconsolidation does not always occur when a memory is retrieved: The relevance of the reminder structure
A bridge over troubled water: reconsolidation as a link between cognitive and neuroscientific memory research traditions.
TLDR
Concepts developed in neuroscience to phenomena revealed in cognitive psychology to illustrate how these twins separated at birth may be reunited again are applied.
Reconsolidation of memory after its reactivation
Reconsolidation of declarative memory in humans.
TLDR
Evidence for both consolidation and reconsolidation in a paired-associate learning in human declarative memory is provided as backing the universality of this phenomenon and having potential clinical relevance.
...
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