Does PKM(zeta) maintain memory?

@article{Kwapis2014DoesPM,
  title={Does PKM(zeta) maintain memory?},
  author={Janine L. Kwapis and Fred J. Helmstetter},
  journal={Brain research bulletin},
  year={2014},
  volume={105},
  pages={36-45}
}
Work on the long-term stability of memory has identified a potentially critical role for protein kinase Mzeta (PKMζ) in maintaining established memory. PKMζ, an autonomously active isoform of PKC, is hypothesized to sustain those changes that occurred during memory formation in order to preserve the memory engram over time. Initial studies investigating the role of PKMζ were largely successful in demonstrating a role for the kinase in memory maintenance; disrupting PKMζ activity with… CONTINUE READING