Does Metformin affect ER, PR, IGF-1R, β-catenin and PAX-2 expression in women with diabetes mellitus and endometrial cancer?

@inproceedings{Markowska2013DoesMA,
  title={Does Metformin affect ER, PR, IGF-1R, β-catenin and PAX-2 expression in women with diabetes mellitus and endometrial cancer?},
  author={Anna I. Markowska and Monika Pawałowska and Violetta V Filas and Konstanty Korski and Marian Gryboś and S. Linn Sajdak and Anita Olejek and Wiesława Bednarek and Beata Śpiewankiewicz and Jolanta Lubin and Janina Markowska},
  booktitle={Diabetology & metabolic syndrome},
  year={2013}
}
ObjectiveDiabetes mellitus, as a risk factor for endometrial cancer (EC), causes an increase in insulin and IGF-1 concentrations in the blood serum. The increase in insulin and IGF-1 are considered mitogenic factors contributory to cancer development. Studies suggest that metformin has preventive activity, decreasing mortality and the risk of neoplasms. Since estrogen (ER), progesterone (PR) and IGF-1 (IGF-1R) receptor expression and β-catenin and PAX-2 mutations are significant in the… CONTINUE READING
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Hormones and endometrial carcinogenesis.

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