Does M. tuberculosis genomic diversity explain disease diversity?

  title={Does M. tuberculosis genomic diversity explain disease diversity?},
  author={Mireilla Coscolla and S{\'e}bastien Gagneux},
  journal={Drug discovery today. Disease mechanisms},
  volume={7 1},
The outcome of tuberculosis infection and disease is highly variable. This variation has been attributed primarily to host and environmental factors, but better understanding of the global genomic diversity in the M. tuberculosis complex (MTBC) suggests that bacterial factors could also be involved. Review of nearly 100 published reports shows that MTBC strains differ in their virulence and immunogenicity in experimental models, but whether this phenotypic variation plays a role in human… CONTINUE READING

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