Does Inflammation Predispose to Recurrent Vascular Events after Recent Transient Ischaemic Attack and Minor Stroke? the North West of England Transient Ischaemic Attack and Minor Stroke (NORTHSTAR) Study

@article{Selvarajah2011DoesIP,
  title={Does Inflammation Predispose to Recurrent Vascular Events after Recent Transient Ischaemic Attack and Minor Stroke? the North West of England Transient Ischaemic Attack and Minor Stroke (NORTHSTAR) Study},
  author={J. Selvarajah and Craig J. Smith and S. Hulme and R. Georgiou and C. Sherrington and J. Staniland and K. Illingworth and F. Jury and A. Payton and W. Ollier and A. Vail and N. Rothwell and S. Hopkins and P. Tyrrell},
  journal={International Journal of Stroke},
  year={2011},
  volume={6},
  pages={187 - 194}
}
Background and hypothesis Inflammation is implicated in the pathogenesis and outcome of ischaemic injury. Poststroke inflammation is associated with outcome but it remains unclear whether such inflammation precedes or results from ischaemic injury. We hypothesised that inflammatory markers are associated with an increased risk of recurrent vascular events soon after transient ischaemic attack and minor stroke. Methods This was a multicentre, prospective, nested case–control study. Plasma… Expand
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References

SHOWING 1-10 OF 43 REFERENCES
Prognosis in patients with transient ischaemic attack (TIA) and minor stroke attending TIA services in the North West of England: The NORTHSTAR Study
TLDR
Current provision of TIA services, where delayed presentation to “rapid access” TIA clinics is common, does not appear to provide an appropriate setting for urgent evaluation, risk stratification or timely secondary prevention for those who may be at highest risk of stroke. Expand
Inflammation and ischaemic stroke
TLDR
It remains to be established whether the inflammatory response is a truly independent risk factor in general, or whether specific anti-inflammatory interventions are beneficial either in prevention or acute treatment. Expand
Fibrinogen Concentration and Risk of Ischemic Stroke and Acute Coronary Events in 5113 Patients With Transient Ischemic Attack and Minor Ischemic Stroke
TLDR
Risks of recurrent ischemic stroke and acute coronary events increase linearly with fibrinogen levels, but the relationships are weaker than in some previous population-based studies. Expand
An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis
TLDR
The very early increase in concentrations of inflammatory markers after stroke may either be induced by stroke itself, or may indicate a preexisting inflammatory condition in stroke patients which may contribute to the development of stroke. Expand
Plasma Concentration of C-Reactive Protein and Risk of Ischemic Stroke and Transient Ischemic Attack: The Framingham Study
TLDR
Elevated plasma CRP levels significantly predict the risk of future ischemic stroke and TIA in the elderly, independent of other cardiovascular risk factors. Expand
Transient ischemic attacks: stratifying risk.
TLDR
5 risk factors independently associated with a higher 3-month risk of recurrent stroke in a large emergency department–based TIA cohort were identified and sex, ethnicity, previous diagnoses of coronary artery disease or hypertension, current cigarette smoking, antiplatelet or anticoagulant-use at presentation and presentation blood pressure did not predict early stroke. Expand
Acute ischaemic stroke and infection: recent and emerging concepts
TLDR
There is evidence from experimental and clinical settings of impaired immunity or brain-induced immunodepression after stroke, and greater understanding of the relation between inflammation and both infection and ischaemic mechanisms is needed. Expand
Cytokine-induced inflammation and long-term stroke functional outcome
TLDR
It is suggested that in addition to clinical evaluation and neuroimaging, measurement of ESR may be useful for the early detection of stroke patients with poor long-term functional outcome. Expand
A comparison of risk factors and prognosis for transient ischemic attacks and minor ischemic strokes. The Oxfordshire Community Stroke Project.
TLDR
The similarity of the two groups suggests that in many situations, including in clinical trials of treatments for the secondary prevention of strokes, the arbitrary distinction between them could be dispensed with. Expand
C-Reactive Protein as a Predictor of Incident Ischemic Stroke Among Patients With Preexisting Cardiovascular Disease
TLDR
These findings demonstrate the risk prediction for incident ischemic stroke conferred by CRP levels in patients at high risk, and demonstrate the efficacy of bezafibrate, a fibric acid derivative, versus placebo for secondary prevention. Expand
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