Does Huntingtin play a role in selective macroautophagy?

Abstract

The accumulation of protein aggregates in neurons appears to be a basic feature of neurodegenerative disease. In Huntington's Disease (HD), a progressive and ultimately fatal neurodegenerative disorder caused by an expansion of the polyglutamine repeat within the protein Huntingtin (Htt), the immediate proximal cause of disease is well understood. However… (More)
DOI: 10.4161/cc.9.17.12671

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