Does Dietary Cholesterol Matter?

@article{Grundy2016DoesDC,
  title={Does Dietary Cholesterol Matter?},
  author={S. Grundy},
  journal={Current Atherosclerosis Reports},
  year={2016},
  volume={18},
  pages={1-7}
}
  • S. Grundy
  • Published 2016
  • Medicine
  • Current Atherosclerosis Reports
An ongoing dispute in the nutrition field is whether dietary cholesterol contributes significantly to elevated serum cholesterol and to atherosclerotic disease. Carefully controlled metabolic studies have shown that high-cholesterol intakes cause moderate increases in serum cholesterol levels. It is been difficult to verify this in population studies because of confounding factors. Nonetheless, meta-analysis of controlled studies documents a cholesterol-raising action of dietary cholesterol… Expand
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References

SHOWING 1-10 OF 72 REFERENCES
Heterogeneity of cholesterol homeostasis in man. Response to changes in dietary fat quality and cholesterol quantity.
TLDR
The results demonstrate that the responses to dietary cholesterol and fat are highly individualized and that most individuals have effective feedback control mechanisms. Expand
Dietary cholesterol from eggs increases the ratio of total cholesterol to high-density lipoprotein cholesterol in humans: a meta-analysis.
TLDR
Dietary cholesterol raises the ratio of total to HDL cholesterol and, therefore, adversely affects the cholesterol profile, and the advice to limit cholesterol intake by reducing consumption of eggs and other cholesterol-rich foods may still be valid. Expand
Effects of dietary cholesterol on serum cholesterol: a meta-analysis and review.
  • P. Hopkins
  • Biology, Medicine
  • The American journal of clinical nutrition
  • 1992
TLDR
Possible reasons for the hyperbolic shape of the relationship between change in serum cholesterol and added dietary cholesterol, mechanisms for individual responsiveness to dietaryolesterol, and important implications regarding interpretation of prior studies and public health issues are discussed. Expand
Dietary cholesterol, heart disease risk and cognitive dissonance
  • D. McNamara
  • Medicine
  • Proceedings of the Nutrition Society
  • 2014
TLDR
The preponderance of the clinical and epidemiological data accumulated since the original dietary cholesterol restrictions were formulated indicate that: (1) dietary cholesterol has a small effect on the plasma cholesterol levels and (2) the lack of a significant relationship between cholesterol intake and heart disease incidence reported from numerous epidemiological surveys. Expand
Serum cholesterol response to changes in the diet: II. The effect of cholesterol in the diet.
The series of metabolic ward experiments, with 22 physically healthy men in each, covered dietary cholesterol intakes from 50 to 1450 mg. daily, with all other variables controlled. TheExpand
Quantitative effects of dietary fat on serum cholesterol in man.
TLDR
It is shown that minimal levels of serum cholesterol were achieved with oils with an iodine number of about 100, and that more highly unsaturated oils were not more effective, which implies that monounsaturated acids are half as effective as the diene, linoleic acid, the primary polyunsaturated acid in vegetable oils. Expand
Serum cholesterol response to changes in the diet: II. The effect of cholesterol in the diet☆
The series of metabolic ward experiments, with 22 physically healthy men in each, covered dietary cholesterol intakes from 50 to 1450 mg. daily, with all other variables controlled. TheExpand
The Interaction of Dietary Cholesterol and Specific Fatty Acids in the Regulation of LDL Receptor Activity and Plasma LDL‐Cholesterol Concentrations a
TLDR
It is now clear that the magnitude of these specific responses to dietary cholesterol and specific fatty acids varies in different individuals with different genetic backgrounds from the same species, and the reasons for this variability are another area of research of considerable importance to human biology. Expand
Characteristics of human hypo- and hyperresponders to dietary cholesterol.
TLDR
A low habitual cholesterol intake, a high serum HDL2 cholesterol level, or a low body weight do not make one less susceptible to dietary cholesterol-induced hypercholesterolemia. Expand
Serum-cholesterol response to dietary cholesterol: a re-evaluation.
  • D. Hegsted
  • Medicine
  • The American journal of clinical nutrition
  • 1986
TLDR
The data from the literature in which the serum-cholesterol response has been measured following a change in cholesterol intake have been re-evaluated and it is concluded that over the range of cholesterol intakes of practical interest the usual response is approximately linear. Expand
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4
5
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